Reaction Details |
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Target | Renin |
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Ligand | BDBM50006152 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_195792 (CHEMBL802392) |
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pH | 6±n/a |
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IC50 | 3±n/a nM |
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Comments | extracted |
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Citation | Baker, WR; Fung, AK; Kleinert, HD; Stein, HH; Plattner, JJ; Armiger, YL; Condon, SL; Cohen, J; Egan, DA; Barlow, JL Nonpeptide renin inhibitors employing a novel 3-aza(or oxa)-2,4-dialkyl glutaric acid moiety as a P2/P3 amide bond replacement. J Med Chem35:1722-34 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50006152 |
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n/a |
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Name | BDBM50006152 |
Synonyms: | 2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid (1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-amide | CHEMBL49286 |
Type | Small organic molecule |
Emp. Form. | C36H60N2O7 |
Mol. Mass. | 632.8708 |
SMILES | CCCC[C@H](O[C@@H](Cc1ccccc1)C(=O)N1CCC(CC1)OCOC)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)CC(C)C |
Structure |
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