| Reaction Details |
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 | Report a problem with these data |
| Target | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 |
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| Ligand | BDBM107664 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1685727 |
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| IC50 | >10000±n/a nM |
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| Citation |  Zhuang, L; Tice, CM; Xu, Z; Zhao, W; Cacatian, S; Ye, YJ; Singh, SB; Lindblom, P; McKeever, BM; Krosky, PM; Zhao, Y; Lala, D; Kruk, BA; Meng, S; Howard, L; Johnson, JA; Bukhtiyarov, Y; Panemangalore, R; Guo, J; Guo, R; Himmelsbach, F; Hamilton, B; Schuler-Metz, A; Schauerte, H; Gregg, R; McGeehan, GM; Leftheris, K; Claremon, DA Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11? hydroxysteroid dehydrogenase type 1 inhibitor. Bioorg Med Chem25:3649-3657 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 |
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| Name: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 |
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| Synonyms: | 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II | 3BHS2_HUMAN | HSD3B2 | HSDB3B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42057.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_768821 |
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| Residue: | 372 |
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| Sequence: | MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFI
YTSSIEVAGPNSYKEIIQNGHEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDTLY
TCALRPTYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALR
DPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLDSRWSLPLTLMYWIGFLLEVV
SFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLV
DRHKETLKSKTQ
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| BDBM107664 |
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| n/a |
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| Name | BDBM107664 |
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| Synonyms: | US8575157, 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32N2O4 |
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| Mol. Mass. | 460.5647 |
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| SMILES | C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C)c(=O)c1 |r| |
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| Structure | 
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