Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50254814 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1686958 (CHEMBL4037437) |
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IC50 | 6±n/a nM |
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Citation | Yang, B; Vasbinder, MM; Hird, AW; Su, Q; Wang, H; Yu, Y; Toader, D; Lyne, PD; Read, JA; Breed, J; Ioannidis, S; Deng, C; Grondine, M; DeGrace, N; Whitston, D; Brassil, P; Janetka, JW Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. J Med Chem61:1061-1073 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50254814 |
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n/a |
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Name | BDBM50254814 |
Synonyms: | CHEMBL4059912 |
Type | Small organic molecule |
Emp. Form. | C20H22N4OS |
Mol. Mass. | 366.48 |
SMILES | C[C@H]1NCCC[C@@H]1Nc1ncc(C(N)=O)c2sc(cc12)-c1ccccc1 |r| |
Structure |
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