| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-serine O-palmitoleoyltransferase porcupine |
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| Ligand | BDBM50257134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1689461 |
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| IC50 | 24±n/a nM |
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| Citation |  Ho, SY; Alam, J; Jeyaraj, DA; Wang, W; Lin, GR; Ang, SH; Tan, ESW; Lee, MA; Ke, Z; Madan, B; Virshup, DM; Ding, LJ; Manoharan, V; Chew, YS; Low, CB; Pendharkar, V; Sangthongpitag, K; Hill, J; Keller, TH; Poulsen, A Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors. J Med Chem60:6678-6692 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-serine O-palmitoleoyltransferase porcupine |
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| Name: | Protein-serine O-palmitoleoyltransferase porcupine |
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| Synonyms: | MG61 | MG61 | PORC | PORCN | PORCN_HUMAN | PPN | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52337.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103574 |
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| Residue: | 461 |
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| Sequence: | MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
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| BDBM50257134 |
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| n/a |
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| Name | BDBM50257134 |
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| Synonyms: | CHEMBL4066798 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N6O3S |
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| Mol. Mass. | 396.423 |
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| SMILES | Cn1c2ncn(CC(=O)Nc3ccc(cc3)-c3nccs3)c2c(=O)n(C)c1=O |
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| Structure | 
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