Reaction Details |
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Target | Protein-serine O-palmitoleoyltransferase porcupine |
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Ligand | BDBM50133870 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1689460 (CHEMBL4040030) |
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IC50 | 0.400000±n/a nM |
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Citation | Ho, SY; Alam, J; Jeyaraj, DA; Wang, W; Lin, GR; Ang, SH; Tan, ESW; Lee, MA; Ke, Z; Madan, B; Virshup, DM; Ding, LJ; Manoharan, V; Chew, YS; Low, CB; Pendharkar, V; Sangthongpitag, K; Hill, J; Keller, TH; Poulsen, A Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors. J Med Chem60:6678-6692 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein-serine O-palmitoleoyltransferase porcupine |
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Name: | Protein-serine O-palmitoleoyltransferase porcupine |
Synonyms: | MG61 | MG61 | PORC | PORCN | PORCN_HUMAN | PPN | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine |
Type: | PROTEIN |
Mol. Mass.: | 52337.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_103574 |
Residue: | 461 |
Sequence: | MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
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BDBM50133870 |
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n/a |
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Name | BDBM50133870 |
Synonyms: | CHEBI:78030 | CHEMBL3188386 | US10251893, Compound 86 |
Type | Small organic molecule |
Emp. Form. | C23H20N6O |
Mol. Mass. | 396.4445 |
SMILES | Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C |
Structure |
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