| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Smoothened homolog |
|---|
| Ligand | BDBM24498 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1690630 |
|---|
| Ki | 42±n/a nM |
|---|
| Citation |  Morgillo, F; Amendola, G; Della Corte, CM; Giacomelli, C; Botta, L; Di Maro, S; Messere, A; Ciaramella, V; Taliani, S; Marinelli, L; Trincavelli, ML; Martini, C; Novellino, E; Ciardiello, F; Cosconati, S Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer. J Med Chem60:7447-7458 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Smoothened homolog |
|---|
| Name: | Smoothened homolog |
|---|
| Synonyms: | G-protein- coupled-like receptor Smoothened (Smo) | SMO | SMOH | SMO_HUMAN | Smoothened homolog |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 86415.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99835 |
|---|
| Residue: | 787 |
|---|
| Sequence: | MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
|
|
|
|---|
| BDBM24498 |
|---|
| n/a |
|---|
| Name | BDBM24498 |
|---|
| Synonyms: | 3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-1-(2-phenylacetyl)thiourea | CHEMBL254760 | US10464902, MGCD-265 | thieno[3,2-b]pyridine-based inhibitor, 10a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H20FN5O2S2 |
|---|
| Mol. Mass. | 517.598 |
|---|
| SMILES | Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1 |
|---|
| Structure | 
|
|---|
Search and Browse
