| Reaction Details |
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 | Report a problem with these data |
| Target | Polycomb protein EED |
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| Ligand | BDBM50259911 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1691994 |
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| IC50 | 119000±n/a nM |
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| Citation |  Lingel, A; Sendzik, M; Huang, Y; Shultz, MD; Cantwell, J; Dillon, MP; Fu, X; Fuller, J; Gabriel, T; Gu, J; Jiang, X; Li, L; Liang, F; McKenna, M; Qi, W; Rao, W; Sheng, X; Shu, W; Sutton, J; Taft, B; Wang, L; Zeng, J; Zhang, H; Zhang, M; Zhao, K; Lindvall, M; Bussiere, DE Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J Med Chem60:415-427 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polycomb protein EED |
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| Name: | Polycomb protein EED |
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| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
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| Type: | Protein |
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| Mol. Mass.: | 50201.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75530 |
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| Residue: | 441 |
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| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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| BDBM50259911 |
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| n/a |
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| Name | BDBM50259911 |
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| Synonyms: | CHEMBL4063710 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18FNO |
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| Mol. Mass. | 223.2865 |
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| SMILES | COc1cc(CC2CCCNC2)ccc1F |
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| Structure | 
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