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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 5 activator 1 | ||
| Ligand | BDBM50261187 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695674 (CHEMBL4046564) | ||
| IC50 | 66±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 5 activator 1 | |||
| Name: | Cyclin-dependent kinase 5 activator 1 | ||
| Synonyms: | CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1 | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 5 | ||
| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33308.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cyclin-dependent kinase 5 activator 1 | ||
| Synonyms: | CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35 | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 34077.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15078 | ||
| Residue: | 307 | ||
| Sequence: |
| ||
| BDBM50261187 | |||
| n/a | |||
| Name | BDBM50261187 | ||
| Synonyms: | CHEMBL4082490 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H34N8O3 | ||
| Mol. Mass. | 506.6 | ||
| SMILES | Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NC3CCN(CC3)C(=O)OC(C)(C)C)ncnc12 |r,wU:10.10,12.15,(35.5,-22.63,;34.42,-23.72,;32.93,-23.33,;31.84,-24.42,;32.24,-25.9,;33.73,-26.3,;34.82,-25.21,;34.13,-27.79,;35.63,-28.1,;33.1,-28.93,;31.59,-28.61,;30.31,-29.46,;29.46,-28.16,;30.75,-27.33,;27.95,-27.85,;27.33,-26.44,;25.8,-26.6,;25.48,-28.11,;24.15,-28.88,;22.81,-28.11,;21.47,-28.89,;20.14,-28.12,;18.81,-28.89,;18.81,-30.43,;20.14,-31.2,;21.48,-30.43,;17.48,-31.2,;16.15,-30.44,;17.48,-32.74,;16.15,-33.52,;16.16,-35.05,;14.82,-32.76,;14.81,-34.27,;24.15,-30.42,;25.48,-31.19,;26.82,-30.42,;26.81,-28.88,)| | ||
| Structure | 
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