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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 5 activator 1 | ||
| Ligand | BDBM50261169 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695674 (CHEMBL4046564) | ||
| IC50 | 30±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 5 activator 1 | |||
| Name: | Cyclin-dependent kinase 5 activator 1 | ||
| Synonyms: | CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1 | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 5 | ||
| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33308.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cyclin-dependent kinase 5 activator 1 | ||
| Synonyms: | CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35 | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 34077.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15078 | ||
| Residue: | 307 | ||
| Sequence: |
| ||
| BDBM50261169 | |||
| n/a | |||
| Name | BDBM50261169 | ||
| Synonyms: | CHEMBL4076545 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H30N8O2 | ||
| Mol. Mass. | 462.5474 | ||
| SMILES | CC(=O)N[C@H]1CC[C@@H](CC1)Nc1ncnc2n(cnc12)[C@@H]1C[C@@H](C1)NC(=O)c1cccc(C)n1 |r,wU:7.10,20.22,22.27,wD:4.3,(16.83,-30.61,;16.84,-32.15,;15.51,-32.93,;18.17,-32.92,;19.5,-32.14,;20.84,-32.91,;22.17,-32.13,;22.16,-30.59,;20.83,-29.83,;19.5,-30.6,;23.5,-29.82,;24.83,-30.58,;24.84,-32.12,;26.18,-32.88,;27.5,-32.11,;27.5,-30.57,;28.64,-29.53,;28.01,-28.13,;26.48,-28.3,;26.16,-29.8,;30.14,-29.85,;30.99,-31.14,;32.28,-30.29,;31.43,-29,;33.79,-30.6,;34.81,-29.46,;36.32,-29.77,;34.4,-27.97,;32.91,-27.58,;32.52,-26.09,;33.6,-25,;35.09,-25.39,;36.17,-24.3,;35.49,-26.87,)| | ||
| Structure | 
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