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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 | ||
| Ligand | BDBM50261164 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695679 (CHEMBL4046569) | ||
| IC50 | >1000±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 | |||
| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 | ||
| Synonyms: | CDK4/Cyclin D3 | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of ChEMBL is 1806445 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 4 | ||
| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33731.96 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11802 | ||
| Residue: | 303 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G1/S-specific cyclin-D3 | ||
| Synonyms: | CCND3 | CCND3_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32521.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P30281 | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| BDBM50261164 | |||
| n/a | |||
| Name | BDBM50261164 | ||
| Synonyms: | CHEMBL4103221 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22ClN7O | ||
| Mol. Mass. | 447.92 | ||
| SMILES | Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCc3cccc(Cl)c3)ncnc12 |r,wU:12.15,10.10,(26.01,-22.02,;24.92,-23.11,;23.43,-22.71,;22.35,-23.8,;22.75,-25.29,;24.23,-25.68,;25.32,-24.6,;24.63,-27.17,;26.14,-27.49,;23.6,-28.32,;22.09,-28,;20.8,-28.83,;19.97,-27.54,;21.26,-26.71,;18.46,-27.22,;17.83,-25.81,;16.3,-25.98,;15.98,-27.48,;14.65,-28.26,;13.31,-27.48,;11.98,-28.26,;10.65,-27.48,;10.65,-25.94,;9.31,-25.18,;7.98,-25.94,;7.98,-27.48,;6.64,-28.26,;9.31,-28.26,;14.65,-29.8,;15.98,-30.56,;17.31,-29.8,;17.31,-28.26,)| | ||
| Structure | 
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