Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Ligand | BDBM50261210 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695672 (CHEMBL4046562) | ||
| IC50 | 474±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-A2/Cyclin-dependent kinase 2 | |||
| Name: | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2-CyclinA | CDK2/A | CDK2/Cyclin A | CDK2/Cyclin A2 | Cyclin A2/dependent kinase 2 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-Dependent Kinase 2 (CDK2A) | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | Cdk2/Cyclin A kinase was purified from insect cells coinfected with Cyclin A/Cdk2 baculovirus. | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33938.17 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P24941 | ||
| Residue: | 298 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cyclin-A2 | ||
| Synonyms: | CCN1 | CCNA | CCNA1 | CCNA2 | CCNA2_HUMAN | Cyclin A | Cyclin-A | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48550.19 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20248 | ||
| Residue: | 432 | ||
| Sequence: |
| ||
| BDBM50261210 | |||
| n/a | |||
| Name | BDBM50261210 | ||
| Synonyms: | CHEMBL4104979 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H28N8O2 | ||
| Mol. Mass. | 448.5208 | ||
| SMILES | CC(=O)N1CCC(CC1)Nc1ncnc2n(cnc12)[C@@H]1C[C@@H](C1)NC(=O)c1cccc(C)n1 |r,wU:19.21,21.26,(17.13,-19.64,;18.45,-20.43,;18.43,-21.97,;19.8,-19.68,;21.12,-20.47,;22.46,-19.73,;22.49,-18.19,;21.17,-17.39,;19.82,-18.14,;23.84,-17.44,;25.16,-18.23,;25.13,-19.77,;26.45,-20.56,;27.8,-19.82,;27.82,-18.28,;28.99,-17.27,;28.38,-15.85,;26.85,-15.98,;26.5,-17.48,;30.49,-17.61,;31.3,-18.92,;32.61,-18.1,;31.79,-16.79,;34.11,-18.45,;35.16,-17.32,;36.66,-17.66,;34.79,-15.83,;33.31,-15.4,;32.93,-13.91,;34.04,-12.84,;35.52,-13.26,;36.63,-12.19,;35.89,-14.75,)| | ||
| Structure | 
| ||