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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Ligand | BDBM50261167 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695672 (CHEMBL4046562) | ||
| IC50 | 38±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-A2/Cyclin-dependent kinase 2 | |||
| Name: | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2-CyclinA | CDK2/A | CDK2/Cyclin A | CDK2/Cyclin A2 | Cyclin A2/dependent kinase 2 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-Dependent Kinase 2 (CDK2A) | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | Cdk2/Cyclin A kinase was purified from insect cells coinfected with Cyclin A/Cdk2 baculovirus. | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33938.17 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P24941 | ||
| Residue: | 298 | ||
| Sequence: |
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| Component 2 | |||
| Name: | Cyclin-A2 | ||
| Synonyms: | CCN1 | CCNA | CCNA1 | CCNA2 | CCNA2_HUMAN | Cyclin A | Cyclin-A | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48550.19 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20248 | ||
| Residue: | 432 | ||
| Sequence: |
| ||
| BDBM50261167 | |||
| n/a | |||
| Name | BDBM50261167 | ||
| Synonyms: | CHEMBL4105016 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H24N8O | ||
| Mol. Mass. | 476.5325 | ||
| SMILES | O=C(N[C@H]1C[C@H](C1)n1cnc2c(NCc3cccnc3)ncnc12)c1cccc(n1)-c1ccccc1 |r,wU:5.7,3.2,(29.63,-26.83,;28.12,-26.52,;27.09,-27.66,;25.59,-27.34,;24.29,-28.19,;23.45,-26.89,;24.74,-26.05,;21.95,-26.58,;21.32,-25.17,;19.78,-25.33,;19.46,-26.84,;18.13,-27.61,;16.8,-26.84,;15.47,-27.61,;14.13,-26.84,;12.8,-27.62,;11.47,-26.85,;11.47,-25.31,;12.8,-24.54,;14.13,-25.3,;18.13,-29.15,;19.47,-29.92,;20.81,-29.15,;20.81,-27.61,;27.72,-25.03,;26.23,-24.63,;25.83,-23.15,;26.92,-22.06,;28.41,-22.45,;28.8,-23.94,;29.49,-21.36,;29.09,-19.88,;30.18,-18.79,;31.67,-19.18,;32.06,-20.67,;30.98,-21.76,)| | ||
| Structure | 
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