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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 5 activator 1 | ||
| Ligand | BDBM50261203 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695674 (CHEMBL4046564) | ||
| IC50 | 34±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 5 activator 1 | |||
| Name: | Cyclin-dependent kinase 5 activator 1 | ||
| Synonyms: | CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1 | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 5 | ||
| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33308.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cyclin-dependent kinase 5 activator 1 | ||
| Synonyms: | CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35 | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 34077.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15078 | ||
| Residue: | 307 | ||
| Sequence: |
| ||
| BDBM50261203 | |||
| n/a | |||
| Name | BDBM50261203 | ||
| Synonyms: | CHEMBL4067461 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H21Cl2N7O | ||
| Mol. Mass. | 482.365 | ||
| SMILES | Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCc3ccc(Cl)c(Cl)c3)ncnc12 |r,wU:12.15,10.10,(32.81,-21.74,;31.71,-22.82,;30.22,-22.42,;29.14,-23.52,;29.54,-25,;31.02,-25.4,;32.11,-24.31,;31.42,-26.88,;32.93,-27.21,;30.39,-28.04,;28.88,-27.71,;27.59,-28.55,;26.76,-27.26,;28.05,-26.42,;25.25,-26.94,;24.62,-25.53,;23.09,-25.69,;22.77,-27.2,;21.44,-27.97,;20.1,-27.2,;18.77,-27.97,;17.44,-27.2,;17.44,-25.66,;16.1,-24.89,;14.77,-25.66,;13.43,-24.89,;14.77,-27.2,;13.43,-27.97,;16.1,-27.97,;21.44,-29.51,;22.77,-30.28,;24.1,-29.51,;24.1,-27.97,)| | ||
| Structure | 
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