Reaction Details |
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Target | P2X purinoceptor 7 |
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Ligand | BDBM254266 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1703451 (CHEMBL4054684) |
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Ki | 5.0±n/a nM |
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Citation | Letavic, MA; Savall, BM; Allison, BD; Aluisio, L; Andres, JI; De Angelis, M; Ao, H; Beauchamp, DA; Bonaventure, P; Bryant, S; Carruthers, NI; Ceusters, M; Coe, KJ; Dvorak, CA; Fraser, IC; Gelin, CF; Koudriakova, T; Liang, J; Lord, B; Lovenberg, TW; Otieno, MA; Schoetens, F; Swanson, DM; Wang, Q; Wickenden, AD; Bhattacharya, A 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate. J Med Chem60:4559-4572 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68602.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99572 |
Residue: | 595 |
Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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BDBM254266 |
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n/a |
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Name | BDBM254266 |
Synonyms: | US10112937, Example 158 | US10150765, Example 158 | US10703749, Example 158 | US9464084, 158 |
Type | Small organic molecule |
Emp. Form. | C18H13ClF4N6O |
Mol. Mass. | 440.782 |
SMILES | C[C@H]1N(CCc2c1nnn2-c1ncc(F)cn1)C(=O)c1cccc(c1Cl)C(F)(F)F |r| |
Structure |
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