| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM50277622 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1718274 (CHEMBL4133274) |
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| Ki | 860±n/a nM |
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| Citation |  Diab, S; Abdelaziz, AM; Li, P; Teo, T; Basnet, SKC; Noll, B; Rahaman, MH; Lu, J; Hou, J; Yu, M; Le, BT; Albrecht, H; Milne, RW; Wang, S Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia. Eur J Med Chem139:762-772 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 51342.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BUB5 |
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| Residue: | 465 |
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| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
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| BDBM50277622 |
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| n/a |
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| Name | BDBM50277622 |
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| Synonyms: | CHEMBL4162390 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N5O2S |
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| Mol. Mass. | 371.457 |
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| SMILES | COc1ccc(Nc2nccc(n2)-c2sc(nc2C)N(C)C)c(OC)c1 |
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| Structure | 
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