| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50015915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63651 |
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| IC50 | 400±n/a nM |
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| Citation |  Finke, PE; Ashe, BM; Knight, WB; Maycock, AL; Navia, MA; Shah, SK; Thompson, KR; Underwood, DJ; Weston, H; Zimmerman, M Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides. J Med Chem33:2522-8 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50015915 |
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| n/a |
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| Name | BDBM50015915 |
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| Synonyms: | 4-{[((6R,7S)-3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl)-methyl-amino]-methyl}-benzoic acid | 4-{[(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl)-methyl-amino]-methyl}-benzoic acid | CHEMBL73255 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O9S |
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| Mol. Mass. | 466.462 |
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| SMILES | CO[C@@H]1[C@@H]2N(C1=O)C(C(=O)N(C)Cc1ccc(cc1)C(O)=O)=C(COC(C)=O)CS2(=O)=O |t:23| |
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| Structure | 
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