Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50015930 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63658 |
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IC50 | 940.0±n/a nM |
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Citation | Shah, SK; Brause, KA; Chandler, GO; Finke, PE; Ashe, BM; Weston, H; Knight, WB; Maycock, AL; Doherty, JB Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins. J Med Chem33:2529-35 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50015930 |
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n/a |
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Name | BDBM50015930 |
Synonyms: | 7-Methoxy-5,5,8-trioxo-3-phenylsulfanylmethyl-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester | CHEMBL310354 |
Type | Small organic molecule |
Emp. Form. | C19H23NO6S2 |
Mol. Mass. | 425.519 |
SMILES | CO[C@@H]1C2N(C1=O)C(C(=O)OC(C)(C)C)=C(CSc1ccccc1)CS2(=O)=O |t:15| |
Structure |
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