| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50292233 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1731684 (CHEMBL4147220) |
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| IC50 | 52±n/a nM |
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| Citation |  Jin, K; Yin, H; De Clercq, E; Pannecouque, C; Meng, G; Chen, F Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1. Eur J Med Chem145:726-734 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50292233 |
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| n/a |
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| Name | BDBM50292233 |
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| Synonyms: | CHEMBL4175919 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19F2N5 |
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| Mol. Mass. | 427.4487 |
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| SMILES | Cc1cc(cc(C)c1Nc1ccnc(Nc2ccc(cc2)C#N)n1)-c1cc(F)cc(F)c1 |
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| Structure | 
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