| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C epsilon type |
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| Ligand | BDBM50455602 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1754793 (CHEMBL4189553) |
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| IC50 | 230±n/a nM |
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| Citation |  Kwiatkowski, J; Liu, B; Tee, DHY; Chen, G; Ahmad, NHB; Wong, YX; Poh, ZY; Ang, SH; Tan, ESW; Ong, EH; Nurul Dinie, na; Poulsen, A; Pendharkar, V; Sangthongpitag, K; Lee, MA; Sepramaniam, S; Ho, SY; Cherian, J; Hill, J; Keller, TH; Hung, AW Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem61:4386-4396 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C epsilon type |
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| Name: | Protein kinase C epsilon type |
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| Synonyms: | KPCE_HUMAN | PKC epsilon | PKCE | PRKCE | Protein kinase C epsilon | Protein kinase C epsilon type | Protein kinase C, PKC; classical/novel | Protein kinase C, epsilon | nPKC-epsilon |
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| Type: | Enzyme |
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| Mol. Mass.: | 83680.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 737 |
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| Sequence: | MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT
NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE
PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP
TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN
MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA
KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE
NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG
KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD
RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL
DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED
AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI
NQEEFKGFSYFGEDLMP
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| BDBM50455602 |
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| n/a |
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| Name | BDBM50455602 |
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| Synonyms: | CHEMBL4216507 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19N5O |
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| Mol. Mass. | 381.4299 |
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| SMILES | COc1cc2CNCc2cc1-c1cnn2ccc(cc12)-c1ccnc2[nH]ccc12 |
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| Structure | 
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