| Reaction Details |
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 | Report a problem with these data |
| Target | Free fatty acid receptor 1 |
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| Ligand | BDBM50456564 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1757348 (CHEMBL4192356) |
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| EC50 | <1000±n/a nM |
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| Citation |  Li, Z; Liu, C; Xu, X; Qiu, Q; Su, X; Dai, Y; Yang, J; Li, H; Shi, W; Liao, C; Pan, M; Huang, W; Qian, H Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. Eur J Med Chem138:458-479 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Free fatty acid receptor 1 |
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| Name: | Free fatty acid receptor 1 |
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| Synonyms: | FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 31473.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14842 |
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| Residue: | 300 |
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| Sequence: | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP
LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP
CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG
PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY
NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
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| BDBM50456564 |
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| n/a |
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| Name | BDBM50456564 |
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| Synonyms: | CHEMBL4218291 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28O6S |
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| Mol. Mass. | 468.562 |
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| SMILES | COc1cc(C)c(c(C)c1)-c1cccc(COc2ccc(cc2)S(=O)(=O)C(C)(C)C(O)=O)c1 |
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| Structure | 
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