| Reaction Details |
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 | Report a problem with these data |
| Target | Tolloid-like protein 1 |
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| Ligand | BDBM50458766 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1764656 (CHEMBL4199903) |
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| Ki | 0.031±n/a nM |
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| Citation |  Kallander, LS; Washburn, D; Hilfiker, MA; Eidam, HS; Lawhorn, BG; Prendergast, J; Fox, R; Dowdell, S; Manns, S; Hoang, T; Zhao, S; Ye, G; Hammond, M; Holt, DA; Roethke, T; Hong, X; Reid, RA; Gampe, R; Zhang, H; Diaz, E; Rendina, AR; Quinn, AM; Willette, B Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Med Chem Lett9:736-740 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tolloid-like protein 1 |
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| Name: | Tolloid-like protein 1 |
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| Synonyms: | 3.4.24.- | TLL | TLL1 | TLL1_HUMAN | Tolloid-like protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 114697.38 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117909 |
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| Residue: | 1013 |
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| Sequence: | MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFW
GDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGF
GLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQ
AMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVH
ELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYA
RNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNL
SSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLL
GRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPD
DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYD
KPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCA
CEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKF
EFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSK
KGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHS
PSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETE
KSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDL
YSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAV
GLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK
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| BDBM50458766 |
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| n/a |
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| Name | BDBM50458766 |
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| Synonyms: | CHEMBL4212386 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H40N4O11 |
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| Mol. Mass. | 632.6588 |
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| SMILES | CCCCC[C@H]([C@@H](CC)N(O)C=O)C(=O)NCNC(=O)c1ccc(o1)-c1ccc(C(=O)N[C@@H](CC(O)=O)C(O)=O)c(OCC)c1 |r| |
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| Structure | 
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