Reaction Details |
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Target | Renin |
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Ligand | BDBM50022591 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_195773 |
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IC50 | 20±n/a nM |
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Citation | Bühlmayer, P; Caselli, A; Fuhrer, W; Göschke, R; Rasetti, V; Rüeger, H; Stanton, JL; Criscione, L; Wood, JM Synthesis and biological activity of some transition-state inhibitors of human renin. J Med Chem31:1839-46 (1988) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50022591 |
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n/a |
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Name | BDBM50022591 |
Synonyms: | 2,2-Dimethyl-propionic acid 1-[1-(4-{1-[1-carbamoyl-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-hydroxy-1-isobutyl-5-methyl-hexylcarbamoyl)-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-1-phenyl-ethyl ester | CHEMBL54655 |
Type | Small organic molecule |
Emp. Form. | C44H67N9O8 |
Mol. Mass. | 850.0583 |
SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](CC(O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C(C)(OC(=O)C(C)(C)C)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |
Structure |
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