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TargetAurora kinase B
LigandBDBM50460791
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1770329 (CHEMBL4222441)
EC50<16±n/a nM
Citation Yu, TZhang, YKerekes, ADTagat, JRDoll, RJXiao, YEsposite, SHruza, ABelanger, DBVoss, MRainka, MPBasso, ALiu, MLiang, LSui, NPrelusky, DRindgen, DZhang, L Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor. Bioorg Med Chem Lett28:1397-1403 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50460791
n/a
NameBDBM50460791
Synonyms:CHEMBL4227284
TypeSmall organic molecule
Emp. Form.C24H25N9S
Mol. Mass.471.581
SMILESCc1cn2c(cnc2c(Nc2cc(ns2)C(N2CCCCC2)c2ccccn2)n1)-c1cn[nH]c1
Structure
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