Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM103290 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1772222 (CHEMBL4224334) |
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IC50 | 41±n/a nM |
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Citation | Boga, SB; Alhassan, AB; Cooper, AB; Doll, R; Shih, NY; Shipps, G; Deng, Y; Zhu, H; Nan, Y; Sun, R; Zhu, L; Desai, J; Patel, M; Muppalla, K; Gao, X; Wang, J; Yao, X; Kelly, J; Gudipati, S; Paliwal, S; Tsui, HC; Wang, T; Sherborne, B; Xiao, L; Hruza, A; Buevich, A; Zhang, LK; Hesk, D; Samatar, AA; Carr, D; Long, B; Black, S; Dayananth, P; Windsor, W; Kirschmeier, P; Bishop, R Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. Bioorg Med Chem Lett28:2029-2034 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
Type: | Ser/Thr Protein Kinase |
Mol. Mass.: | 41392.76 |
Organism: | Homo sapiens (Human) |
Description: | P28482 |
Residue: | 360 |
Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM103290 |
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n/a |
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Name | BDBM103290 |
Synonyms: | US8546404, 412 |
Type | Small organic molecule |
Emp. Form. | C37H36FN7O3 |
Mol. Mass. | 645.7252 |
SMILES | COC[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 |r,c:13| |
Structure |
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