| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor p65 |
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| Ligand | BDBM50463331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1778023 (CHEMBL4235015) |
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| IC50 | 1500±n/a nM |
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| Citation |  Ren, Y; Anaya-Eugenio, GD; Czarnecki, AA; Ninh, TN; Yuan, C; Chai, HB; Soejarto, DD; Burdette, JE; de Blanco, EJC; Kinghorn, AD Cytotoxic and NF-?B and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. Bioorg Med Chem26:4452-4460 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor p65 |
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| Name: | Transcription factor p65 |
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| Synonyms: | NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60211.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q04206 |
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| Residue: | 551 |
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| Sequence: | MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
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| BDBM50463331 |
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| n/a |
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| Name | BDBM50463331 |
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| Synonyms: | CHEMBL4204109 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H48O5 |
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| Mol. Mass. | 500.7098 |
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| SMILES | [H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C(O)=O)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(=O)OC)C(C)=C |r| |
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| Structure | 
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