| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Toll-like receptor 9 |
|---|
| Ligand | BDBM50467775 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1796971 (CHEMBL4269088) |
|---|
| IC50 | 30±n/a nM |
|---|
| Citation |  Paul, B; Rahaman, O; Roy, S; Pal, S; Satish, S; Mukherjee, A; Ghosh, AR; Raychaudhuri, D; Bhattacharya, R; Goon, S; Ganguly, D; Talukdar, A Activity-guided development of potent and selective toll-like receptor 9 antagonists. Eur J Med Chem159:187-205 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Toll-like receptor 9 |
|---|
| Name: | Toll-like receptor 9 |
|---|
| Synonyms: | CD_antigen: CD289 | TLR9 | TLR9_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 115889.91 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NR96 |
|---|
| Residue: | 1032 |
|---|
| Sequence: | MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA
PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL
AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY
KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL
ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN
ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF
GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV
DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS
RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS
FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL
RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL
RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF
FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA
VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG
WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG
RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE
DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF
YNRNFCQGPTAE
|
|
|
|---|
| BDBM50467775 |
|---|
| n/a |
|---|
| Name | BDBM50467775 |
|---|
| Synonyms: | CHEMBL4278682 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H54N8O2 |
|---|
| Mol. Mass. | 594.8343 |
|---|
| SMILES | COc1cc2c(nc(NCCCN3CCN(C)CC3)nc2cc1OCCCN1CCCC1)N1CCN(CC1)C1CCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
