| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50470591 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205398 (CHEMBL817415) |
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| Ki | <10000±n/a nM |
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| Citation |  Smith, PW; Cooper, AW; Bell, R; Beresford, IJ; Gore, PM; McElroy, AB; Pritchard, JM; Saez, V; Taylor, NR; Sheldrick, RL New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists. J Med Chem38:3772-9 (1995) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46261.42 |
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| Organism: | GUINEA PIG |
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| Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
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| BDBM50470591 |
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| n/a |
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| Name | BDBM50470591 |
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| Synonyms: | CHEMBL124208 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26FN3O2 |
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| Mol. Mass. | 407.4805 |
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| SMILES | Fc1ccc2[nH]cc(CCN3CCC4(CN(Cc5ccccc5)C(=O)O4)CC3)c2c1 |
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| Structure | 
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