| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50027185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304067 (CHEMBL839742) |
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| Ki | 0.794328±n/a nM |
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| Citation |  Atkinson, PJ; Bromidge, SM; Duxon, MS; Gaster, LM; Hadley, MS; Hammond, B; Johnson, CN; Middlemiss, DN; North, SE; Price, GW; Rami, HK; Riley, GJ; Scott, CM; Shaw, TE; Starr, KR; Stemp, G; Thewlis, KM; Thomas, DR; Thompson, M; Vong, AK; Watson, JM 3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity. Bioorg Med Chem Lett15:737-41 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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| BDBM50027185 |
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| n/a |
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| Name | BDBM50027185 |
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| Synonyms: | CHEMBL183921 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N3O5 |
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| Mol. Mass. | 411.451 |
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| SMILES | CC(COc1ccc2OCC(=O)Nc2c1)NCC(O)COc1cccc2[nH]ccc12 |
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| Structure | 
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