| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM50150945 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_313606 (CHEMBL826108) |
|---|
| EC50 | 0.125893±n/a nM |
|---|
| Citation |  Kitbunnadaj, R; Hashimoto, T; Poli, E; Zuiderveld, OP; Menozzi, A; Hidaka, R; de Esch, IJ; Bakker, RA; Menge, WM; Yamatodani, A; Coruzzi, G; Timmerman, H; Leurs, R N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. J Med Chem48:2100-7 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48691.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
|
|
|
|---|
| BDBM50150945 |
|---|
| n/a |
|---|
| Name | BDBM50150945 |
|---|
| Synonyms: | CHEBI:81390 | Immepip |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H15N3 |
|---|
| Mol. Mass. | 165.2355 |
|---|
| SMILES | C(C1CCNCC1)c1c[nH]cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
