Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAlpha-2C adrenergic receptor
LigandBDBM50048866
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1804485 (CHEMBL4303088)
Ki 479±n/a nM
Citation Gordon, DE; Jang, GM; Bouhaddou, M; Xu, J; Obernier, K; White, KM; O'Meara, MJ; Rezelj, VV; Guo, JZ; Swaney, DL; Tummino, TA; Hüttenhain, R; Kaake, RM; Richards, AL; Tutuncuoglu, B; Foussard, H; Batra, J; Haas, K; Modak, M; Kim, M; Haas, P; Polacco, BJ; Braberg, H; Fabius, JM; Eckhardt, M; Soucheray, M; Bennett, MJ; Cakir, M; McGregor, MJ; Li, Q; Meyer, B; Roesch, F; Vallet, T; Mac Kain, A; Miorin, L; Moreno, E; Naing, ZZC; Zhou, Y; Peng, S; Shi, Y; Zhang, Z; Shen, W; Kirby, IT; Melnyk, JE; Chorba, JS; Lou, K; Dai, SA; Barrio-Hernandez, I; Memon, D; Hernandez-Armenta, C; Lyu, J; Mathy, CJP; Perica, T; Pilla, KB; Ganesan, SJ; Saltzberg, DJ; Rakesh, R; Liu, X; Rosenthal, SB; Calviello, L; Venkataramanan, S; Liboy-Lugo, J; Lin, Y; Huang, XP; Liu, Y; Wankowicz, SA; Bohn, M; Safari, M; Ugur, FS; Koh, C; Savar, NS; Tran, QD; Shengjuler, D; Fletcher, SJ; O'Neal, MC; Cai, Y; Chang, JCJ; Broadhurst, DJ; Klippsten, S; Sharp, PP; Wenzell, NA; Kuzuoglu-Ozturk, D; Wang, HY; Trenker, R; Young, JM; Cavero, DA; Hiatt, J; Roth, TL; Rathore, U; Subramanian, A; Noack, J; Hubert, M; Stroud, RM; Frankel, AD; Rosenberg, OS; Verba, KA; Agard, DA; Ott, M; Emerman, M; Jura, N; von Zastrow, M; Verdin, E; Ashworth, A; Schwartz, O; d'Enfert, C; Mukherjee, S; Jacobson, M; Malik, HS; Fujimori, DG; Ideker, T; Craik, CS; Floor, SN; Fraser, JS; Gross, JD; Sali, A; Roth, BL; Ruggero, D; Taunton, J; Kortemme, T; Beltrao, P; Vignuzzi, M; García-Sastre, A; Shokat, KM; Shoichet, BK; Krogan, NJ A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature583:459-468 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-2C adrenergic receptor
Name:Alpha-2C adrenergic receptor
Synonyms:ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:Enzyme
Mol. Mass.:49552.32
Organism:Homo sapiens (Human)
Description:P18825
Residue:462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50048866
n/a
NameBDBM50048866
Synonyms:1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-piperazine | 1-cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl)piperazine | 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)propyl]piperazine | 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine | CHEMBL53325 | PB-28
TypeSmall organic molecule
Emp. Form.C24H38N2O
Mol. Mass.370.5713
SMILESCOc1cccc2C(CCCN3CCN(CC3)C3CCCCC3)CCCc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: