Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50484978 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_813460 (CHEMBL2019356) |
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IC50 | 5850±n/a nM |
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Citation | Ding, M; He, F; Hudyma, TW; Zheng, X; Poss, MA; Kadow, JF; Beno, BR; Rigat, KL; Wang, YK; Fridell, RA; Lemm, JA; Qiu, D; Liu, M; Voss, S; Pelosi, LA; Roberts, SB; Gao, M; Knipe, J; Gentles, RG Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett22:2866-71 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | 2.7.7.48 | NS5b | RNA-directed RNA polymerase |
Type: | PROTEIN |
Mol. Mass.: | 65779.30 |
Organism: | Hepacivirus C |
Description: | ChEMBL_118447 |
Residue: | 591 |
Sequence: | SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIR
SVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGSSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVCGDDLVVICESAGTQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIP
AASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
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BDBM50484978 |
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n/a |
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Name | BDBM50484978 |
Synonyms: | CHEMBL2017857 |
Type | Small organic molecule |
Emp. Form. | C36H38N4O5 |
Mol. Mass. | 606.7107 |
SMILES | OC(=O)\C=C\c1ccc(NC(=O)C2(CCCC2)NC(=O)c2ccc3c(C4CCCCC4)c4-c5ncoc5CCCn4c3c2)cc1 |
Structure |
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