| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 11 |
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| Ligand | BDBM50537599 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1969967 (CHEMBL4602785) |
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| IC50 | 3030±n/a nM |
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| Citation |  Roy, SM; Minasov, G; Arancio, O; Chico, LW; Van Eldik, LJ; Anderson, WF; Pelletier, JC; Watterson, DM A Selective and Brain Penetrant p38?MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction. J Med Chem62:5298-5311 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 11 |
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| Name: | Mitogen-activated protein kinase 11 |
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| Synonyms: | MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41351.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_20128774 |
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| Residue: | 364 |
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| Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
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| BDBM50537599 |
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| n/a |
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| Name | BDBM50537599 |
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| Synonyms: | CHEMBL4648060 | US11149020, Compound 2 (MW-108) |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N4 |
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| Mol. Mass. | 326.3944 |
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| SMILES | CN(C)c1cc(-c2ccncc2)c(nn1)-c1ccc2ccccc2c1 |
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| Structure | 
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