| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50489338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_933737 (CHEMBL2320839) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Wu, WL; Asberom, T; Bara, T; Bennett, C; Burnett, DA; Clader, J; Domalski, M; Greenlee, WJ; Josien, H; McBriar, M; Rajagopalan, M; Vicarel, M; Xu, R; Hyde, LA; Del Vecchio, RA; Cohen-Williams, ME; Song, L; Lee, J; Terracina, G; Zhang, Q; Nomeir, A; Parker, EM; Zhang, L Structure activity relationship studies of tricyclic bispyran sulfone ?-secretase inhibitors. Bioorg Med Chem Lett23:844-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50489338 |
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| n/a |
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| Name | BDBM50489338 |
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| Synonyms: | CHEMBL2314613 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20F4O6S2 |
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| Mol. Mass. | 508.504 |
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| SMILES | [H][C@@]12COc3c(F)ccc(F)c3[C@@]1(CCO[C@H]2CCS(C)(=O)=O)S(=O)(=O)c1ccc(F)c(F)c1 |r| |
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| Structure | 
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