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TargetPresenilin-1
LigandBDBM50492092
Substrate/Competitorn/a
Meas. Tech.ChEMBL_968577 (CHEMBL2401297)
IC50 1.9±n/a nM
Citation Ye, XMKonradi, AWSun, MYuan, SAubele, DLDappen, MDressen, DGarofalo, AWJagodzinski, JJLatimer, LProbst, GDSham, HLWone, DXu, YZNess, DBrigham, EKwong, GTWilltis, CTonn, GGoldbach, EQuinn, KPZhang, HHSauer, JMBova, MBasi, GS Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ?-secretase inhibitors. Bioorg Med Chem Lett23:996-1000 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Presenilin-1
Name:Presenilin-1
Synonyms:3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:n/a
Mol. Mass.:52657.13
Organism:Homo sapiens (Human)
Description:P49768
Residue:467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50492092
n/a
NameBDBM50492092
Synonyms:CHEMBL2396961
TypeSmall organic molecule
Emp. Form.C19H13ClF3N3O2S
Mol. Mass.439.839
SMILES[H][C@]12Cc3n[nH]cc3[C@]([H])(N1S(=O)(=O)c1cccc(c1)C(F)(F)F)c1ccc(Cl)cc21 |r,THB:11:10:30.24:2.7.3|
Structure
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