Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50492092 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_968577 (CHEMBL2401297) |
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IC50 | 1.9±n/a nM |
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Citation | Ye, XM; Konradi, AW; Sun, M; Yuan, S; Aubele, DL; Dappen, M; Dressen, D; Garofalo, AW; Jagodzinski, JJ; Latimer, L; Probst, GD; Sham, HL; Wone, D; Xu, YZ; Ness, D; Brigham, E; Kwong, GT; Willtis, C; Tonn, G; Goldbach, E; Quinn, KP; Zhang, HH; Sauer, JM; Bova, M; Basi, GS Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ?-secretase inhibitors. Bioorg Med Chem Lett23:996-1000 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50492092 |
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n/a |
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Name | BDBM50492092 |
Synonyms: | CHEMBL2396961 |
Type | Small organic molecule |
Emp. Form. | C19H13ClF3N3O2S |
Mol. Mass. | 439.839 |
SMILES | [H][C@]12Cc3n[nH]cc3[C@]([H])(N1S(=O)(=O)c1cccc(c1)C(F)(F)F)c1ccc(Cl)cc21 |r,THB:11:10:30.24:2.7.3| |
Structure |
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