Reaction Details |
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Target | Reverse transcriptase |
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Ligand | BDBM50492162 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_968173 (CHEMBL2399276) |
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IC50 | 5.8±n/a nM |
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Citation | Sturino, CF; Bousquet, Y; James, CA; DeRoy, P; Duplessis, M; Edwards, PJ; Halmos, T; Minville, J; Morency, L; Morin, S; Thavonekham, B; Tremblay, M; Duan, J; Ribadeneira, M; Garneau, M; Pelletier, A; Tremblay, S; Lamorte, L; Bethell, R; Cordingley, MG; Rajotte, D; Simoneau, B Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors. Bioorg Med Chem Lett23:3967-75 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase |
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Name: | Reverse transcriptase |
Synonyms: | n/a |
Type: | Protein |
Mol. Mass.: | 29598.37 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WKE8 |
Residue: | 254 |
Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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BDBM50492162 |
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n/a |
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Name | BDBM50492162 |
Synonyms: | CHEMBL2397549 |
Type | Small organic molecule |
Emp. Form. | C24H25N7O3 |
Mol. Mass. | 459.5004 |
SMILES | CC[C@H]1C[C@H](CCO1)n1c2c(oc3ccc(nc23)-c2cn(C)cn2)c(nc1=O)-c1cnn(C)c1 |r| |
Structure |
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