Ki Summary

Reaction Details

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Target

Melanin-concentrating hormone receptor 1

Ligand

BDBM50492350

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_971499 (CHEMBL2406561)

IC50

32±n/a nM

Citation

Qian, Y; Conde-Knape, K; Erickson, SD; Falcioni, F; Gillespie, P; Hakimi, I; Mennona, F; Ren, Y; Salari, H; So, SS; Tilley, JW Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs. Bioorg Med Chem Lett23:4216-20 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanin-concentrating hormone receptor 1

Name:

Melanin-concentrating hormone receptor 1

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

45976.27

Organism:

Homo sapiens (Human)

Description:

Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.

Residue:

422

Sequence:

MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT

BDBM50492350

n/a

Name

BDBM50492350

Synonyms:

CHEMBL2403858

Type

Small organic molecule

Emp. Form.

C26H31Cl2N3O

Mol. Mass.

472.45

SMILES

CC(C)(O)c1nc2cc(Cl)ccc2n1[C@@H]1CC[C@@H](CC1)NCC1Cc2ccc(Cl)cc2C1 |r,wU:14.15,17.22,(36.22,-8.65,;37,-9.99,;37.77,-8.65,;38.46,-10.52,;35.83,-10.99,;34.33,-10.62,;33.52,-11.94,;32,-12.21,;31.48,-13.66,;29.97,-13.94,;32.47,-14.84,;33.99,-14.57,;34.52,-13.12,;35.94,-12.54,;37.28,-13.32,;37.22,-14.88,;38.53,-15.69,;39.89,-14.98,;39.94,-13.41,;38.62,-12.59,;41.22,-15.76,;42.56,-15.01,;42.57,-13.47,;41.33,-12.55,;41.82,-11.09,;41.07,-9.76,;41.84,-8.44,;43.38,-8.45,;44.16,-7.13,;44.13,-9.79,;43.35,-11.11,;43.82,-12.57,)|

Structure