| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
|---|
| Ligand | BDBM50495323 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1283917 (CHEMBL3106530) |
|---|
| Ki | 358±n/a nM |
|---|
| Citation |  Szermerski, M; Melesina, J; Wichapong, K; Löppenberg, M; Jose, J; Sippl, W; Holl, R Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors. Bioorg Med Chem22:1016-28 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase |
|---|
| Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
|---|
| Synonyms: | LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 33952.00 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | P0A725 |
|---|
| Residue: | 305 |
|---|
| Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
SAVLA
|
|
|
|---|
| BDBM50495323 |
|---|
| n/a |
|---|
| Name | BDBM50495323 |
|---|
| Synonyms: | CHEMBL3103548 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H28N2O6 |
|---|
| Mol. Mass. | 440.4889 |
|---|
| SMILES | OC[C@H](O[C@H](CO)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1)C(=O)NO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
