| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Ligand | BDBM50495792 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1288264 (CHEMBL3117338) |
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| IC50 | 57±n/a nM |
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| Citation |  Goto, T; Shiina, A; Murata, T; Tomii, M; Yamazaki, T; Yoshida, K; Yoshino, T; Suzuki, O; Sogawa, Y; Mizukami, K; Takagi, N; Yoshitomi, T; Etori, M; Tsuchida, H; Mikkaichi, T; Nakao, N; Takahashi, M; Takahashi, H; Sasaki, S Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors. Bioorg Med Chem Lett24:893-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
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| Type: | Protein |
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| Mol. Mass.: | 83318.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07343 |
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| Residue: | 736 |
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| Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
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| BDBM50495792 |
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| n/a |
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| Name | BDBM50495792 |
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| Synonyms: | CHEMBL3114923 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18FN3O2S |
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| Mol. Mass. | 395.45 |
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| SMILES | OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2cccc(F)c2)cc1 |
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| Structure | 
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