| Reaction Details |
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 | Report a problem with these data |
| Target | N-lysine methyltransferase KMT5A |
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| Ligand | BDBM50498721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520241 (CHEMBL3626067) |
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| IC50 | 8700±n/a nM |
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| Citation |  Ma, A; Yu, W; Xiong, Y; Butler, KV; Brown, PJ; Jin, J Structure-activity relationship studies of SETD8 inhibitors. Medchemcomm5:1892-1898 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-lysine methyltransferase KMT5A |
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| Name: | N-lysine methyltransferase KMT5A |
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| Synonyms: | KMT5A | KMT5A_HUMAN | N-lysine methyltransferase SETD8 | PRSET7 | SET domain-containing protein 8 (SetD8) | SET07 | SET8 | SETD8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42919.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NQR1 |
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| Residue: | 393 |
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| Sequence: | MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAA
AAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHH
EVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPK
TPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQ
SEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKRE
ALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLI
LIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
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| BDBM50498721 |
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| n/a |
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| Name | BDBM50498721 |
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| Synonyms: | CHEMBL3621704 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H38N6O3 |
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| Mol. Mass. | 470.6076 |
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| SMILES | COc1cc2c(NCCCCCN3CCCC3)nc(nc2cc1OCCNC=O)N1CCCC1 |
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| Structure | 
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