| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA:cholesterol acyltransferase |
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| Ligand | BDBM50047498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28199 (CHEMBL637692) |
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| IC50 | 410±n/a nM |
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| Citation |  Kimura, T; Takase, Y; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Yamada, T; Fujimori, T; Saitou, I Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. J Med Chem36:1630-40 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA:cholesterol acyltransferase |
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| Name: | Acyl-CoA:cholesterol acyltransferase |
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| Synonyms: | ACAT |
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| Type: | n/a |
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| Mol. Mass.: | 35405.31 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | n/a |
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| Residue: | 305 |
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| Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
|
|
|
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| BDBM50047498 |
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| n/a |
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| Name | BDBM50047498 |
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| Synonyms: | 1-{2-Dimethylamino-5-[3-(5-methyl-4-phenyl-imidazol-1-yl)-propoxy]-phenyl}-3-pentyl-urea | CHEMBL41992 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H37N5O2 |
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| Mol. Mass. | 463.615 |
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| SMILES | CCCCCNC(=O)Nc1cc(OCCCn2cnc(c2C)-c2ccccc2)ccc1N(C)C |
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| Structure | 
|
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