Reaction Details |
| Report a problem with these data |
Target | Acyl-CoA:cholesterol acyltransferase |
---|
Ligand | BDBM50047599 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_28332 |
---|
IC50 | 19±n/a nM |
---|
Citation | Kimura, T; Watanabe, N; Matsui, M; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Kabayashi, H; Akasaka, K Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2. J Med Chem36:1641-53 (1993) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Acyl-CoA:cholesterol acyltransferase |
---|
Name: | Acyl-CoA:cholesterol acyltransferase |
Synonyms: | ACAT |
Type: | n/a |
Mol. Mass.: | 35405.31 |
Organism: | Oryctolagus cuniculus |
Description: | n/a |
Residue: | 305 |
Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
|
|
|
BDBM50047599 |
---|
n/a |
---|
Name | BDBM50047599 |
Synonyms: | 1-{2-[3-(5-Methyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methylsulfanyl-phenyl}-3-pentyl-urea | CHEMBL297553 |
Type | Small organic molecule |
Emp. Form. | C26H34N4O2S |
Mol. Mass. | 466.639 |
SMILES | CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1SC |
Structure |
|