| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA:cholesterol acyltransferase |
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| Ligand | BDBM50047599 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28334 (CHEMBL645898) |
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| IC50 | 230±n/a nM |
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| Citation |  Kimura, T; Watanabe, N; Matsui, M; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Kabayashi, H; Akasaka, K Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2. J Med Chem36:1641-53 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Acyl-CoA:cholesterol acyltransferase |
|---|
| Name: | Acyl-CoA:cholesterol acyltransferase |
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| Synonyms: | ACAT |
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| Type: | n/a |
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| Mol. Mass.: | 35405.31 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | n/a |
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| Residue: | 305 |
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| Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
|
|
|
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| BDBM50047599 |
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| n/a |
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| Name | BDBM50047599 |
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| Synonyms: | 1-{2-[3-(5-Methyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methylsulfanyl-phenyl}-3-pentyl-urea | CHEMBL297553 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N4O2S |
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| Mol. Mass. | 466.639 |
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| SMILES | CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1SC |
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| Structure | 
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