Reaction Details |
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Target | Acyl-CoA:cholesterol acyltransferase |
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Ligand | BDBM50047546 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_28332 |
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IC50 | 48±n/a nM |
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Citation | Kimura, T; Watanabe, N; Matsui, M; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Kabayashi, H; Akasaka, K Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2. J Med Chem36:1641-53 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Acyl-CoA:cholesterol acyltransferase |
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Name: | Acyl-CoA:cholesterol acyltransferase |
Synonyms: | ACAT |
Type: | n/a |
Mol. Mass.: | 35405.31 |
Organism: | Oryctolagus cuniculus |
Description: | n/a |
Residue: | 305 |
Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
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BDBM50047546 |
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n/a |
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Name | BDBM50047546 |
Synonyms: | 1-{2-[3-(5-Chloro-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenyl}-3-(2,2-dimethyl-propyl)-urea | CHEMBL44848 |
Type | Small organic molecule |
Emp. Form. | C25H31ClN4O2 |
Mol. Mass. | 454.992 |
SMILES | Cc1cccc(OCCCn2cnc(c2Cl)-c2ccccc2)c1NC(=O)NCC(C)(C)C |
Structure |
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