| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50049236 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_202112 (CHEMBL808970) |
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| IC50 | 169±n/a nM |
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| Citation |  Magnin, DR; Biller, SA; Chen, Y; Dickson, JK; Fryszman, OM; Lawrence, RM; Logan, JV; Sieber-McMaster, ES; Sulsky, RB; Traeger, SC; Hsieh, DC; Lan, SJ; Rinehart, JK; Harrity, TW; Jolibois, KG; Kunselman, LK; Rich, LC; Slusarchyk, DA; Ciosek, CP alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase. J Med Chem39:657-60 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50049236 |
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| n/a |
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| Name | BDBM50049236 |
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| Synonyms: | (+/-)-1-Phosphono-4-(3-phenoxyphenyl)butylsulfonic Acid Tripotassium Salt | CHEMBL351151 | Tripotassium salt of 4-(3-Phenoxy-phenyl)-1-phosphono-butane-1-sulfonic acid | potassium salt of 4-(3-Phenoxy-phenyl)-1-phosphono-butane-1-sulfonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16O7PS |
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| Mol. Mass. | 383.334 |
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| SMILES | [O-]P([O-])(=O)C(CCCc1cccc(Oc2ccccc2)c1)S([O-])(=O)=O |
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| Structure | 
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