Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50499976 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1541258 (CHEMBL3742564) | ||
IC50 | 66±n/a nM | ||
Citation | Mougenot, P; Namane, C; Fett, E; Goumy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Ménegotto, J; Schmidt, F; Venier, O; Viviani, F; Nicolai, E Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors. Bioorg Med Chem Lett26:25-32 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50499976 | |||
n/a | |||
Name | BDBM50499976 | ||
Synonyms: | CHEMBL3740753 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H29N3O4S | ||
Mol. Mass. | 443.559 | ||
SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(COC2CCCC2)s1 |r,wU:7.10,wD:4.3,(-5.61,6,;-6.67,5.39,;-7.74,6,;-6.67,3.85,;-5.34,3.08,;-5.34,1.54,;-4,.77,;-2.67,1.54,;-2.67,3.08,;-4.01,3.85,;-1.33,.77,;,1.54,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,;2.67,-1.54,;3.73,-.93,;2.66,-3.08,;4,-3.86,;4.14,-5.38,;5.65,-5.7,;6.42,-4.36,;7.94,-4.2,;8.57,-2.79,;10.1,-2.63,;10.85,-1.3,;12.36,-1.62,;12.52,-3.15,;11.11,-3.77,;5.38,-3.22,)| | ||
Structure |