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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50380029 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1541257 (CHEMBL3742563) | ||
| IC50 | 600±n/a nM | ||
| Citation |  Mougenot, P; Namane, C; Fett, E; Goumy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Ménegotto, J; Schmidt, F; Venier, O; Viviani, F; Nicolai, E Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors. Bioorg Med Chem Lett26:25-32 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50380029 | |||
| n/a | |||
| Name | BDBM50380029 | ||
| Synonyms: | CHEMBL2012627 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H24FN3O3S | ||
| Mol. Mass. | 453.529 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(Cc2ccc(F)cc2)s1 |r,wU:7.10,wD:4.3,(44.87,1.11,;43.33,1.09,;42.57,-.25,;42.54,2.42,;41,2.4,;40.21,3.72,;38.67,3.7,;37.92,2.35,;38.71,1.03,;40.24,1.05,;36.39,2.34,;35.61,3.65,;34.07,3.63,;33.32,2.3,;34.1,.98,;35.64,1,;31.78,2.28,;31,3.61,;31.02,.94,;29.48,.92,;28.56,2.16,;27.1,1.67,;27.12,.13,;25.78,-.63,;24.45,.15,;24.47,1.7,;23.15,2.48,;21.81,1.72,;20.48,2.51,;21.8,.18,;23.12,-.6,;28.59,-.33,)| | ||
| Structure | 
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