| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transitional endoplasmic reticulum ATPase |
|---|
| Ligand | BDBM50500324 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1545550 (CHEMBL3749465) |
|---|
| IC50 | 500±n/a nM |
|---|
| Citation |  Zhou, HJ; Wang, J; Yao, B; Wong, S; Djakovic, S; Kumar, B; Rice, J; Valle, E; Soriano, F; Menon, MK; Madriaga, A; Kiss von Soly, S; Kumar, A; Parlati, F; Yakes, FM; Shawver, L; Le Moigne, R; Anderson, DJ; Rolfe, M; Wustrow, D Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083). J Med Chem58:9480-97 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transitional endoplasmic reticulum ATPase |
|---|
| Name: | Transitional endoplasmic reticulum ATPase |
|---|
| Synonyms: | TERA_HUMAN | Transitional endoplasmic reticulum ATPase | VCP | Valosin containing protein, p97 subunit | Valosin-containing protein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 89300.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P55072 |
|---|
| Residue: | 806 |
|---|
| Sequence: | MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
AGPSQGSGGGTGGSVYTEDNDDDLYG
|
|
|
|---|
| BDBM50500324 |
|---|
| n/a |
|---|
| Name | BDBM50500324 |
|---|
| Synonyms: | CHEMBL3747448 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H25N5O |
|---|
| Mol. Mass. | 411.4989 |
|---|
| SMILES | Cc1cc2c(cccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
