Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCytoplasmic tyrosine-protein kinase BMX
LigandBDBM209866
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1656291 (CHEMBL4005761)
Ki 545±n/a nM
Citation Thorarensen, ADowty, MEBanker, MEJuba, BJussif, JLin, TVincent, FCzerwinski, RMCasimiro-Garcia, AUnwalla, RTrujillo, JILiang, SBalbo, PChe, YGilbert, AMBrown, MFHayward, MMontgomery, JLeung, LYang, XSoucy, SHegen, MCoe, JLangille, JVajdos, FChrencik, JTelliez, JB Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. J Med Chem60:1971-1993 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytoplasmic tyrosine-protein kinase BMX
Name:Cytoplasmic tyrosine-protein kinase BMX
Synonyms:BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK
Type:Tyrosine-protein kinase
Mol. Mass.:78030.42
Organism:Homo sapiens (Human)
Description:P51813
Residue:675
Sequence:
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM209866
n/a
NameBDBM209866
Synonyms:PF-06651600 | US11111242, Example 5 | US20230348487, Example PF-06651600 | US9617258, Example 5
TypeSmall organic molecule
Emp. Form.C15H19N5O
Mol. Mass.285.3443
SMILESC[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: