Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase TXK

Ligand

BDBM209866

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1656293 (CHEMBL4005763)

131±n/a nM

Citation

Thorarensen, A; Dowty, ME; Banker, ME; Juba, B; Jussif, J; Lin, T; Vincent, F; Czerwinski, RM; Casimiro-Garcia, A; Unwalla, R; Trujillo, JI; Liang, S; Balbo, P; Che, Y; Gilbert, AM; Brown, MF; Hayward, M; Montgomery, J; Leung, L; Yang, X; Soucy, S; Hegen, M; Coe, J; Langille, J; Vajdos, F; Chrencik, J; Telliez, JB Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. J Med Chem60:1971-1993 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase TXK

Name:

Tyrosine-protein kinase TXK

Synonyms:

PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK)

Type:

Protein

Mol. Mass.:

61268.80

Organism:

Homo sapiens (Human)

Description:

P42681

Residue:

527

Sequence:

MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW

BDBM209866

n/a

Name

BDBM209866

Synonyms:

PF-06651600 | US11111242, Example 5 | US20230348487, Example PF-06651600 | US9617258, Example 5

Type

Small organic molecule

Emp. Form.

C15H19N5O

Mol. Mass.

285.3443

SMILES

C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|

Structure