| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Blk |
|---|
| Ligand | BDBM209866 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1656310 (CHEMBL4005780) |
|---|
| IC50 | 19000±n/a nM |
|---|
| Citation |  Thorarensen, A; Dowty, ME; Banker, ME; Juba, B; Jussif, J; Lin, T; Vincent, F; Czerwinski, RM; Casimiro-Garcia, A; Unwalla, R; Trujillo, JI; Liang, S; Balbo, P; Che, Y; Gilbert, AM; Brown, MF; Hayward, M; Montgomery, J; Leung, L; Yang, X; Soucy, S; Hegen, M; Coe, J; Langille, J; Vajdos, F; Chrencik, J; Telliez, JB Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. J Med Chem60:1971-1993 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Blk |
|---|
| Name: | Tyrosine-protein kinase Blk |
|---|
| Synonyms: | B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57711.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51451 |
|---|
| Residue: | 505 |
|---|
| Sequence: | MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
|
|
|
|---|
| BDBM209866 |
|---|
| n/a |
|---|
| Name | BDBM209866 |
|---|
| Synonyms: | PF-06651600 | US11111242, Example 5 | US20230348487, Example PF-06651600 | US9617258, Example 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H19N5O |
|---|
| Mol. Mass. | 285.3443 |
|---|
| SMILES | C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
